Qiu Cui, Ph. D.
Group Leader

E-mail: cuiqiu@qibebt.ac.cn

Born in 1975, and an awardee of “CAS Hundred Talents Program”. Dr. Cui received his Ph.D. degree in Molecular Biology at Institute of Biophysics CAS in 2004, and worked first as a postdoc and then as an assistant researcher in University of Wisconsin-Madison from 2004 to 2008. Since 2009, Dr. Cui works as the group leader of metabolomics group of Qingdao Institute of Bioenergy and Bioprocess (QIBEBT). Dr. Cui’s research interest is Metabolomics and Structural Genomics. The central theme of his research focus on key features and bottlenecks in the degradation of lignocellulosic materials, such as screening and structure/function analysis of cellulosomal and noncellulosomal enzymes, rational protein engineering and directed evolution of cellulases or designer cellulosomes, and genetic engineering of lignocellulolytic microorganisms.


  1. Chao Chen, Hongwu Yang, Jinsong Xuan, Qiu Cui, Yingang Feng* (2019) Resonance assignments of a cellulosomal double-dockerin from Clostridium thermocellum. Biomol. NMR Assign. In press.
  2. Shanshan Xu, Dandan Wang, Yuxi Wei, Qiu Cui, Wenli Li* (2018) Marinobacter bohaiensis sp. nov., a moderate halophile isolated from benthic sediment of the Bohai Sea. Int. J. Syst. Evol. Microbiol. 68(11):3534-3539.
  3. Ya-Jun Liu, Kuan Qi, Jie Zhang, Chao Chen, Qiu Cui*, Yingang Feng* (2018) Firmicutes-enriched IS1447 represents a group of IS3-family insertion sequences exhibiting unique +1 transcriptional slippage. Biotechnol. Biofuels 11:300.
  4. Xiaojin Song, Jie Wang, Yanchao Wang, Yingang Feng, Qiu Cui, Yandu Lu* (2018) Artificial creation of Chlorella pyrenoidosa mutants for economic sustainable food production. Bioresour. Technol. 268:340-345.
  5. Lizett Ortiz de Ora, Raphael Lamed, Ya-Jun Liu, Jian Xu, Qiu Cui, Yingang Feng, Yuval Shoham, Edward A. Bayer, Iván Muñoz-Gutiérrez* (2018) Regulation of biomass degradation by alternative σ factors in cellulolytic clostridia. Sci. Rep. 8:11036.
  6. Sheng Dong, Xi Liu, Gu-Zhen Cui, Qiu Cui*, Xinquan Wang*, Yingang Feng* (2018) Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure D(-)-tartaric acid. Chem. Commun.54(61):8482-8485.
  7. Renmin Li, Yingang Feng, Shiyue Liu, Kuan Qi, Qiu Cui*, Ya-Jun Liu* (2018) Inducing effects of cellulosic hydrolysate components of lignocellulose on cellulosome synthesis in Clostridium thermocellum. Microbial Biotechnol.11(5):905-916.
  8. Huidan Zhang, Dong Lu, Xin Li, Yingang Feng, Qiu Cui, Xiaojin Song* (2018) Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield in Mortierella alpine. BMC Biotechnol. 18:23.
  9. Xiaoyi Li†, Yan Xiao†, Yingang Feng, Bin Li, Wenli Li*, Qiu Cui* (2018) The spatial proximity effect of beta-glucosidase and cellulosomes on cellulose degradation. Enzyme Microbial Technol. 115:52-61.
  10. Ya‑Jun Liu†*, Shiyue Liu†, Sheng Dong, Renmin Li, Yingang Feng*, and Qiu Cui* (2018) Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum. Biotechnol. Biofuels 11, 6.
  11. Huidan Zhang, Yingang Feng, Qiu Cui*, and Xiaojin Song* (2017) Expression of Vitreoscilla hemoglobin enhances production of arachidonic acid and lipids in Mortierella alpine. BMC Biotechnol. 17, 68.
  12. Lei Du†, Sheng Dong†, Xingwang Zhang, Chengying Jiang, Jingfei Chen, Lishan Yao, Xiao Wang, Xiaobo Wan, Xi Liu, Xinquan Wang, Shaohua Huang, Qiu Cui, Yingang Feng*, Shuang-Jiang Liu*, and Shengying Li* (2017) Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system. Proc. Natl. Acad. Sci. USA114(26):E5129-E5137.
  13. Zengxin Ma, Miaomiao Tian, Yanzhen Tan, Guzhen Cui, Yingang Feng, Qiu Cui, and Xiaojin Song* (2017) Response mechanism of the docosahexaenoic acid producer Aurantiochytrium under cold stress. Algal Res. 25, 191-199.
  14. Jie Zhang, Shiyue Liu, Renmin Li, Wei Hong, Yan Xiao, Yingang Feng, Qiu Cui* and Ya‑Jun Liu* (2017) Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum. Biotechnol. Biofuels 10, 124.
  15. Patrick K. Chaffey†, Xiaoyang Guan†, Chao Chen, Yuan Ruan, Xingfeng Wang, Amy H. Tran, Theo N. Koelsch, Qiu Cui, Yingang Feng*, and Zhongping Tan* (2017) Structural insight into the stabilizing effect of O-glycosylation. Biochemistry 56(23), 2897-2906.
  16. Xiaojin Song, Zengxin Ma, Yanzhen Tan, Huidan Zhang, Qiu Cui* (2017) Wastewater recycling technology for fermentation in polyunsaturated fatty acid production. Bioresour. Technol. 235,79-86.
  17. Dandan Wang​, Yuxi Wei​, Qiu Cui​, Wenli Li* (2017)​ Amylibacter cionae sp. nov., isolated from the sea squirt Ciona savignyi. Int. J. Syst. Evol. Microbiol. 67(9):3462-3466.
  18. Yu-rong Cheng, Zhi-jie Sun*, Gu-zhen Cui, Xiaojin Song, Qiu Cui* (2016) A new strategy for strain improvement of Aurantiochytrium sp. based on heavy-ions mutagenesis and synergistic effects of cold stress and inhibitors of enoyl-ACP reductase. Enzyme Microbiol. Technol. 93-94,182-190.
  19. Gu-Zhen Cui, Zengxin Ma, Ya-Jun Liu, Yingang Feng, Zhijie Sun, Yurong Cheng, Xiaojin Song*, Qiu Cui (2016) Overexpression of glucose-6-phosphate dehydrogenase enhanced the polyunsaturated fatty acid composition of Aurantiochytrium sp. SD116. Algal Res. 19, 138-145.
  20. Chen Wang, Jinsong Xuan*, Qiu Cui, Yingang Feng* (2016) Resonance assignments of a VapC family toxin from Clostridium thermocellum. Biomol. NMR Assign.10(2), 367-371.
  21. Ya-Jun Liu, Xiaxia Song, Yifei Li, Jinsong Xuan, Qiu Cui, Jinfeng Wang, Yingang Feng* (2016) Low stability of the reduced state of Mycobacterium tuberculosis NrdH redoxin. FEBS Lett. 590(3), 387-395.
  22. Chao Chen, Zhenling Cui, Xiangfei Song, Ya-Jun Liu, Qiu Cui*, and Yingang Feng* (2016) Integration of bacterial expansin-like proteins into cellulosome promotes the cellulose degradation. Appl. Microbiol. Biotechnol. 100(5), 2203-2212.
  23. Chenggang Xu, Ranran Huang, Lin Teng, Xiaoyan Jing, Jianqiang Hu, Guzhen Cui, Yilin Wang, Qiu Cui, Jian Xu* (2015) Cellulosome stoichiometry in Clostridium cellulolyticum is regulated by selective RNA processing and stabilization. Nature Commun. 6:6900.
  24. Zengxin Ma, Yanzhen Tan, Guzhen Cui, Yingang Feng, Qiu Cui* and Xiaojin Song* (2015) Transcriptome and gene expression analysis of DHA producer Aurantiochytrium under low temperature conditions. Sci. Rep. 5, 14446.
  25. Xiaojin Song*, Xiaolong Wang, Yanzhen Tan, Yingang Feng, Wenli Li and Qiu Cui* (2015) High production of squalene using a newly isolated yeast-like strain Pseudozyma sp. SD301. J. Agric. Food Chem. 63(38), 8445-4851.
  26. Yan Xiao, Jingtao Zhang, Jiatao Cui, Xingzhe Yao, Zhijie Sun, Yingang Feng* and Qiu Cui* (2015) Simultaneous accumulation of neutral lipids and biomass in Nannochloropsis oceanica IMET1 under high light intensity and nitrogen replete conditions. Algal Res. 11, 55-62.
  27. Jie Zhang, Ya-Jun Liu*, Gu-Zhen Cui and Qiu Cui* (2015) A novel arabinose-inducible genetic operation system developed for Clostridium cellulolyticum. Biotechnol. Biofuels 8, 36.
  28. Ya-Jun Liu, Jie Zhang, Gu-Zhen Cui and Qiu Cui* (2015) Current progress of targetron technology: Development, improvement and application in metabolic engineering. Biotechnol. J. 10(6), 855-865.
  29. Xingzhe Yao, Yan Xiao, Qiu Cui* and Yingang Feng* (2015) 1H, 15N and 13C resonance assignments of translationally-controlled tumor protein from photosynthetic microalga Nannochloropsis oceanica. Biomol. NMR Assign.9(2), 325-328
  30. Xiaoke Ding, Chao Chen, Qiu Cui, Wenli Li* and Yingang Feng* (2015) Resonance assignments of the periplasmic domain of a cellulose-sensing trans-membrane anti-sigma factor from Clostridium thermocellum. Biomol. NMR Assign. 9(2), 321-324.
  31. Jun Lan, Xiao-jin Song, Yan-zhen Tan, Jian-chun Xu, Qiu Cui and Yin-gang Feng* (2015) Concentration of docosahexaenoic acid in Aurantiochytrium oil by Burkholderia lipase. Food Sci. 36(1), 128-134. (In Chinese)
  32. Chao Chen, Zhenling Cui, Yan Xiao, Qiu Cui, Steven P. Smith, Raphael Lamed, Edward A. Bayer and Yingang Feng* (2014) Revisiting the NMR solution structure of the Cel48S type-I dockerin module from Clostridium thermocellum reveals a cohesin-primed conformation. J. Struct. Biol.188(2), 188-193.
  33. Jun Lan, Yanzhen Tan, Xiaojin Song, Qiu Cui, Yingang Feng* (2014) Investigation on the lipid of Aurantiochytrium sp. SD116 by in-cell NMR. Acta Biophys. Sin. 30(3), 193-206. (In Chinese)
  34. Xin-shu Zhu, Jia-tao Cui, Yin-gang Feng, Jing-tao Zhang*, Qiu Cui* (2014) Metabolomic analysis of Clostridium thermocellum. Chinese J. Magn. Reson. 31(2), 243-252. (In Chinese)
  35. Wei Hong, Jie Zhang, Yingang Feng, Georg Mohr, Alan M. Lambowitz, Gu-Zhen Cui, Ya-Jun Liu*, Qiu Cui* (2014) The contribution of cellulosomal scaffoldins to cellulose hydrolysis by Clostridium thermocellum analyzed by using thermotargetrons. Biotechnol. Biofuels 7, 80.
  36. Yingang Feng*, Xiaxia Song, Jinzhong Lin, Jinsong Xuan, Qiu Cui, Jinfeng Wang (2014) Structure determination of archaea-specific ribosomal protein L46a reveals a novel protein fold. Biochem. Biophys. Res. Commun.450(1), 67-72.
  37. Yajun Liu, Guzhen Cui, Wei Hong, Jie Zhang, Qiu Cui* (2014) Genetic engineering of cellulosome-producing Clostridium strains for cellulosic ethanol production. Chinese J. Bioprocess Engin. 12(1), 55-62. (Review; In Chinese)
  38. Gu-Zhen Cui, Jie Zhang, Wei Hong, Chenggang Xu, Yingang Feng, Qiu Cui*, Ya-Jun Liu* (2014) Improvement of ClosTron for successive gene disruption in Clostridium cellulolyticum using a pyrF-based screening system. App. Microbiol. Biotechnol. 98(1), 313-323.
  39. Jia-tao Cui, Yan-zhen Tan, Qiu Cui, Xiao-jin Song* (2013) The analysis of cofactor changes in product synthesis of marine fungus Aurantiochytrium sp. SD116. Chinese J. Mar. Drugs 32(6), 27-32. (In Chinese)
  40. Xiaojin Song*†, Yanzhen Tan†, Yajun Liu, Jingtao Zhang, Guanglei Liu, Yingang Feng, and Qiu Cui* (2013) Different impact of short-chain fatty acids on saturated and polyunsaturated fatty acid biosynthesis in Aurantiochytrium sp. SD116. J. Agric. Food Chem. 61(41), 9876-9881.
  41. Jiatao Cui, Jingtao Zhang, Xinshu Zhu, Fali Bai, Yingang Feng, Wenna Guan*, and Qiu Cui* (2013) Separation and quantification of water-soluble cellular metabolites in Clostridium thermocellum using liquid chromatography-isotope dilution tandem mass spectrometry. Anal. Lett. 46(17), 2767-2786.
  42. Xinshu Zhu, Jiatao Cui, Yingang Feng, Yun Fa, Jingtao Zhang*, Qiu Cui* (2013) Metabolic Adaption of Ethanol-Tolerant Clostridium thermocellum. PLoS ONE 8(7), e70631.
  43. Georg Mohr, Wei Hong, Jie Zhang, Gu-zhen Cui, Yunfeng Yang, Qiu Cui, Ya-jun Liu*, Alan M. Lambowitz* (2013) A targetron system for gene targeting in thermophiles and its Application in Clostridium thermocellum. PLoS ONE 8(7), e69032.
  44. Tong Li, Yuanyuan Du, Qiu Cui, Jingtao Zhang, Weiming Zhu, Kui Hong and Wenli Li* (2013) Cloning, characterization and heterologous expression of the indolocarbazole biosynthetic gene cluster from marine-derived Streptomyces sanyensis FMA. Mar. Drugs 11(2), 466-488.
  45. Lu Lin, Yuetong Ji, Qichao Tu, Ranran Huang, Lin Teng, Xiaowei Zeng, Houhui Song, Kun Wang, Qian Zhou, Yifei Li, Qiu Cui, Zhili He, Jizhong Zhou and Jian Xu* (2103) Microevolution from shock to adaptation revealed strategies improving ethanol tolerance and production in Thermoanaerobacter. Biotechnol. Biofuels 6,103.
  46. Mang Gao, Xiaojin Song*, Yingang Feng, Wenli Li, and Qiu Cui (2013) Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. J. Oleo Sci. 62(3), 143-151.
  47. Yan Xiao, Jingtao Zhang, Jiatao Cui, Yingang Feng, Qiu Cui* (2013) Metabolic profiles of Nannochloropsis oceanica IMET1 under nitrogen-deficiency stress. Bioresour. Technol. 130, 731-738. (*Corresponding author)
  48. Zhenling Cui, Yifei Li*, Yan Xiao, Yingang Feng, and Qiu Cui* (2013) Resonance assignments of cohesin and dockerin domains from Clostridium acetobutylicum ATCC824. Biomol. NMR Assign. 7(1), 73-76. (*Corresponding author)
  49. Shan Wang, Gu-Zhen Cui, Xiang-Fei Song, Yingang Feng* and Qiu Cui* (2012) Efficiency and stability enhancement of cis-epoxysuccinic acid hydrolase by fusion with a carbohydrate binding module and immobilization onto cellulose. Appl. Biochem. Biotechnol. 168, 708-717. (*Corresponding author)
  50. Gu-Zhen Cui, Shan Wang, Yifei Li, Yi-Jun Tian, Yingang Feng, and Qiu Cui* (2012) High yield recombinant expression, characterization and homology modeling of two types of cis-epoxysuccinic acid hydrolases. Protein J. 31(5), 432-438. (*Corresponding author)
  51. Gu-zhen Cui, Wei Hong, Jie Zhang, Wen-li Li, Yingang Feng, Ya-jun Liu*, and Qiu Cui* (2012) Targeted gene engineering in Clostridium cellulolyticum H10 without methylation. J. Microbiol. Methods 89(3), 201-208. (*Corresponding author)
  52. Jitian Liu, Yu Tang*, Kaigui Wu, Caifeng Bi*, and Qiu Cui* (2012) Conversion of fructose into 5-hydroxymethylfurfural (HMF) and its derivatives promoted by inorganic salt in alcohol. Carbohydr. Res. 350, 20-24. (*Corresponding author)
  53. Xianyang Fang†, Qiu Cui†, Yufeng Tong, Yingang Feng, Lu Shan, Li Huang, Jinfeng Wang* (2008) A stabilizing alpha/beta-hydrophobic core greatly contributes to hyperthermostability of archaeal [P62A]Ssh10b. Biochemistry 47(43), 11212-11221. (†Co-first author)
  54. Qiu Cui, Ian A. Lewis, Adrian D. Hegeman, Mark E. Anderson, Jing Li, Christopher F. Schulte, William M. Westler, Hamid R. Eghbalnia, Michael R. Sussman & John L. Markley (2008) Metabolite identification via the Madison Metabolomics Consortium Database. Nature Biotechnol. 26(2), 162-164.
  55. John L. Markley*, Mark E. Anderson, Qiu Cui, Hamid R. Eghbalnia, Ian A. Lewis, Adrian D. Hegeman, Jing Li, Christopher F. Schulte, Michael R. Sussman, William M. Westler, Eldon L. Ulrich, Zsolt Zolnai (2007): New bioinformatics resources for metabolomics. Pac. Symp. Biocomput. 12, 157-168.
  56. Adrian D. Hegeman, Christopher F. Schulte, Qiu Cui, Ian A. Lewis, Edward L. Huttlin, Hamid Eghbalnia, Amy C. Harms, Eldon L. Ulrich, John L. Markley, and Michael R. Sussman (2007) Stable Isotope Assisted Assignment of Elemental Compositions for Metabolomics. Anal. Chem. 79(18), 6912-6921.
  57. Qiu Cui†, Michael P. Thorgersen†, William M. Westler, John L. Markley, Diana M. Downs* (2006) Solution structure of YggX: a prokaryotic protein involved in Fe(II) trafficking. Proteins 62(3), 578-586. (†Co-first author)
  58. Qiu Cui, Yufeng Tong, Hong Xue, Li Huang, Yingang Feng and Jinfeng Wang* (2003) Two conformations of archaeal Ssh10b: the origin of its temperature dependent interaction with DNA.  J. Biol. Chem. 278(51), 51015-51022.
  59. Yufeng Tong, Qiu Cui, Yingang Feng, Li Huang and Jinfeng Wang* (2002) Letters to the Editor: 1H, 15N, and 13C resonance assignments and secondary structure of the Ssh10b from hyperthermophilic archaeon Sulfolobus shibatae. J. Biomol. NMR, 22(4), 385-386.